IRL 2500

Research use only, not for human use.

IRL 2500 is an effective antagonist of the Endothelin receptor. IRL 2500 suppresses ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo.

IRL 2500 is an effective antagonist of the Endothelin receptor. IRL 2500 suppresses ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo. IRL 2500 displays (IC50:1.3 and 94 nM for ETB and ETA receptors, respectively).(In Vivo):In the anesthetized rat, IRL 2500 (10 mg/kg; i.v.) decreases the IRL 1620-mediated enhances renal vascular resistance. IRL 2500 suppresses the initial transient reduction in mean arterial pressure induced by IRL 1620. IRL 2500 (10 mg/kg; i.v.) pre-treatment reduces the initial vasodepressor response to endothelin-1 and IRL 1620 without altering the secondary and sustained pressor response.

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Others

Other Targets

EGFR

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169545-27-1

573.7

C36H35N3O4

>98% (HPLC)

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CN([C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O)C(=O)c1cc(C)cc(C)c1

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(-20℃)

With Ice Pack

≥ 2 years