IRL 2500 ( —— )

Catalog No. M26720 CAS No. 169545-27-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

IRL 2500
Note

Research use only, not for human use.
Brief Description

IRL 2500 is an effective antagonist of the Endothelin receptor. IRL 2500 suppresses ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo.
Description

IRL 2500 is an effective antagonist of the Endothelin receptor. IRL 2500 suppresses ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo. IRL 2500 displays (IC50:1.3 and 94 nM for ETB and ETA receptors, respectively).(In Vivo):In the anesthetized rat, IRL 2500 (10 mg/kg; i.v.) decreases the IRL 1620-mediated enhances renal vascular resistance. IRL 2500 suppresses the initial transient reduction in mean arterial pressure induced by IRL 1620. IRL 2500 (10 mg/kg; i.v.) pre-treatment reduces the initial vasodepressor response to endothelin-1 and IRL 1620 without altering the secondary and sustained pressor response.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

EGFR
Research Area

——
Indication

——

CAS Number

169545-27-1
Formula Weight

573.7
Molecular Formula

C36H35N3O4
Purity

>98% (HPLC)
Solubility

——
SMILES

CN([C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O)C(=O)c1cc(C)cc(C)c1
Chemical Name

——

1.Ramanadham Jyothi Prasad, et al. 6-7,dialkoxy quinazoline derivatives useful for treatment of cancer related disorders. US 8143250 B2

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